Leukoscan [sulesomab-monoclonal antibody] scintigraphy in infectious bone and joint diseases

When clinical data are insufficient to diagnose infrction of bone or joints, nuclear scanning becomes crucial in making an accurate diagnosis. The efficiency of' technetium-99m antigranulocyte monoclonal antibody Fob fragment [leukoscan] was evaluated in 66 patients with suspected muscloskeletal infection and was compared with technetium- 99m methylene diphosphonate bone scan in 54 patients. The overall sensitivity of leukoscan and MDP bone scan was 94.4% and 86.5% respectively Specificity was 91.6% and 50% respectively, and accuracy was 94% and 85% respectively. Leukoscan is more accurate in detecting bone and joint infection with better sensitivity and specificity compared with MDP bone scan

Myoview [technetium-99m tetrofosmine] scintigraphy of parathyroid gland in primary hyperparathyroidism

Minimal surgical techniques are increasingly used to remove parathyroid adenomas. Such surgery depends on accurate preoperative localization of the parathyroid swelling. The preoperative accuracy of Tc-99m tetrofosmin was evaluated in 45 patients presented with primary hyperparathyroidism and compared with ultrasonography and Tc-99m pertechnetate studies / Thallium-201 [Tc-O[4]/TL-20I] subtraction. The overall sensitivity of Tc-99m tetrofosmin was 88.8% for double phase study and 91.1% for dual tracer subtraction and that for Tc-99mO[4]/TL-201 subtraction was 80% and US was 73.3% with high significant difference. High reliability and accuracy of Tc-99m tetrofosmin in pre-operative localization of parathyroid adenoma